Coumarins and derivatives
Apexbio Technology LLC Palomid 529 914913-88-5 10mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
eMolecules 6-Fluoro-4-hydroxycoumarin | 1G | Ships from Wood Dale, IL | Chem-Impex | 1994-13-4 | MFCD03094006 | MW: 180.13
Chem-Impex | 6-Fluoro-4-hydroxycoumarin | 1G | 1994-13-4 | MFCD07383035 | MW:177.22
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Medchemexpress LLC 7-methoxycoumarin-3-carboxylic acid N-succinimidyl ester | 150321-92-9 | MFCD00467593 | ≥97.0% | 10 MG
7-Methoxycoumarin-3-carboxylic acid, succinimidyl ester is a coumarin-derived, amine-reactive fluorescent labeling reagent used to conjugate peptides and proteins for blue/UV fluorescence detection and intracellular imaging applications. The NHS ester enables efficient coupling to primary amines under mild conditions.
- Amine-reactive N-hydroxysuccinimide (NHS) ester for efficient conjugation.
- Strong blue fluorescence suitable for labeling peptides and proteins.
- Useful for synthesis of hydrophilic dye probes and intracellular viscosity measurements.
- Available in small research pack sizes for mg-scale conjugation experiments.
- Typical purity ≥97% (HPLC); consult the certificate of analysis for batch-specific data.
Cayman Chemical Coumarin Boronic Acid pinacol
A fluorescent probe for detection of peroxynitrite; a more soluble form of CBA; can be used to detect peroxynitrite, hypochlorous acid, and hydrogen peroxide; COH displays ex/em = 332/470 nm, respectively
Medchemexpress LLC Coumarin 343 | 55804-65-4 | MFCD00051335 | 95.7% | 285.30 g/mol | C16H15NO4 | 50 MG
Coumarin 343 (C343) is a hydrophilic fluorescent probe for micro water pools, microfluidic systems, and fluorescence-based assays. Supplied as a solid dye with high purity, it is suitable for analytical measurements and fluorescent labeling. The dye exhibits blue emission with a peak near 425 nm and measurable emission across the 425-550 nm range.
- Hydrophilic fluorescent probe for aqueous microenvironments.
- Emission peak near 425 nm for blue fluorescence detection.
- Emission range 425-550 nm provides a broad detection window.
- High purity (95.7%) suitable for analytical and labeling work.
- Supplied as a solid in small laboratory quantities for convenient handling.