Coumarins and derivatives
Cayman Chemical 4-HydroxycoumarIn 100g
A PARP inhibitor (IC50s 1 1 46 640 9 and 160 nM for PARP1 -2 -3 -6 TNKS1/PARP5a and TNKS2 respectively) induces centrosome declustering (EC50 50 3 nM)
Cayman Chemical 4-HydroxycoumarIn 500g
An analytical reference standard that is structurally similar to known synthetic cannabinoids a potential metabolite of ADB-BUTINACA based on the published metabolism of 4-fluoro ADB-PINACA intended for research and forensic applications
Cayman Chemical ANTIBODY CoumarIn 6 5g
An irreversible inhibitor of BTK (IC50 1 nM) decreases the number of CD69 B cells in isolated whole mouse blood (IC50 200 nM)
Cayman Chemical 7-Acetoxy-4-methylcoumarIn 1g
An inhibitor of USP8 (IC50 280 nM) selective for USP8 over USP7 (IC50 100 UM) increases the level of PD-L1 in H460 cells at 2 UM and PC-9 cells at 2 and 4 UM decreases tumor weight tumor size and lung metastasis and increases CD8 T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day i.p. when combined with an anti-PD-L1 antibody and paclitaxel
Cayman Chemical 7-Acetoxy-4-methylcoumarIn 5g
An inhibitor of USP8 (IC50 280 nM) selective for USP8 over USP7 (IC50 100 UM) increases the level of PD-L1 in H460 cells at 2 UM and PC-9 cells at 2 and 4 UM decreases tumor weight tumor size and lung metastasis and increases CD8 T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day i.p. when combined with an anti-PD-L1 antibody and paclitaxel
TARGETMOL CHEMICALS INC 3-Nitrocoumarin 25MG
Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. 3-Nitrocoumarin (3-nitrochromen-2-one) (3-NC) is a potent and selective Phospholipase C-gamma (PLCgamma) inhibitor. Purity 97.28%
Cayman Chemical 7-AmIno-4-methylcoumarIn 1g
A fluorescent probe for lipid droplets can be used to label cellular neutral lipid contents particularly those localized to lipid droplets in live and fixed cells compatible with epifluorescent confocal and two-photon microscopy as well as flow cytometry ex/em 493/503 nm
Selleck Chemical LLC 7-Methoxycoumarin S5163-25mg
7-Methoxycoumarin (Herniarine) also known as Herniarin is a methoxy derivative of coumarin and substrate for dealkylase It has been used in the synthesis of anti-first-pass effect compounds and detergents
Selleck Chemical LLC Dicoumarol S4299-200mg
Dicoumarol is a competitive NADPH quinone oxidoreductase (NQO1) inhibitor and used as an anticoagulant by interfering with the metabolism of vitamin K
Cayman Chemical 7-EthoxycoumarIn 1g
An EZH2 inhibitor (IC50 11 1 nM) colony formation of primary human CD34 CML stem/progenitor cells at 0 5-5 UM reduces global levels of H3K27me3 in K562 cells induces regression of tumors in an EZH2-driven transgenic mouse model of lung adenocarcinoma at 75 mg/kg per day
Cayman Chemical 7-EthoxycoumarIn 500mg
An a-pyrone fungal metabolite with antifungal activity active against C neoformans A fumigatus A niger and A flavus human mycoses (MICs 1 56-6 25 g/ml) active against a variety of filamentous fungi in a disc assay
Cayman Chemical CoumarIn BoronIc AcId 50mg
A potent inhibitor of phosphatidic acid formation (IC50 0 6 UM) through cytokine-activated LPAAT suppresses the production of IFN-Y inhibits IL-12-mediated STAT-4 activation and enhances glucose-stimulatedBcell insulin secretion reduces the onset of diabetes in a non-obese diabetic mouse model
eMolecules 2,2'-(Octylazanediyl)diethanol | 15520-05-5 | MFCD06252160 | 1g
Combi-Blocks, Inc. | 2,2'-(Octylazanediyl)diethanol | 1g | 603129908 | HA-4628 | 95.000 | 15520-05-5 | MFCD06252160 | 217.353 | C12H27NO2
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